PLATELETS CLUMPED ON BLOOD FILM

If the instruments’ platelet count of a sample is within or above normal range, a count may be given with an added comment noting the presence of platelet clumps and suggesting that the true count is likely higher than reported. From Wikipedia, the free encyclopedia. Journal List Case Rep Hematol v. Medical diagnosis Blood disorders. Articles lacking in-text citations from July All articles lacking in-text citations. Online laboratory continuing education for clinical laboratories and med techs. Capillary collections are prone to clotting and formation of platelet clumps.

Hemoglobin Hgb and WBC were normal. Upon examination of peripheral blood PB smear, clumping of platelets was observed. Susan Lemire asks, “Hi, what are most people doing when platelet clumps are found on the blood smear, but the platelet count is within normal range? Other possible preanalytical factors to consider upon investigating platelet clumps include the collection method, that is, capillary venous or line draws. Table 1 Patient’s CBC and platelet counts over the period of care and follow-up. White Blood Cell Differential Simulator. Platelet clumping can also occur in the presence of EDTA and the platelet count again will be falsely decreased. The phenomenon was not age-related or gender-related, nor was it associated with any particular pathology or use of specific drugs.

If either platelet satellitism or platelet clumping is observed on the peripheral smear, the sample could be recollected using sodium citrate as the anticoagulant.

Platelet Clumps on Blood Film | The Fritsma Factor

Note the larger and more variable in size platelets in the latter all photomicrographs are taken using the same x oil lens. In the case of satellitosis, collect the platelet count specimen in a sodium citrate tube. If the clumping is visible and the number of platelets filj normal, pseudothrombocytopenia may be concluded. White Blood Cell Differential Simulator.

Other possible preanalytical factors to consider upon investigating platelet clumps include the collection method, that is, capillary venous or line draws. This morphologic observation may help further separate the two conditions presumptively upon examination of PB smear; refer to Figure 2 for morphologic comparison and Table 2 for comparative features.

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Pseudothrombocytopenia associated with infectious mononucleosis. Log In Sign up for our mailing list. International Journal of Laboratory Hematology. The platelet count from a tube that contains liquid sodium citrate will need to be corrected for the dilutional effect of the citrate.

Hi, Susan, my hunch is that since we don’t review blood films when the CBC is within acceptable parameters, we probably miss some platelet clumping.

Competing Interests The authors declare that there are no competing interests regarding the publication of this plqtelets.

Pseudothrombocytopenia due to Platelet Clumping: A Case Report and Brief Review of the Literature

Recommendations From a practical laboratory point of view, investigation of platelet clumping may include the following steps until a nonclumping smear is obtained, noting that Steps 3 and 4 are reserved for the rare instances, where Steps 1 and 2 do not resolve the platelet clumping. The patient’s past medical history was significant for Klippel-Feil syndrome and hearing loss. As a means of double checking the results, the patient’s blood sample is often examined under a microscope.

From Wikipedia, the free encyclopedia. American Journal of Hematology.

Pseudothrombocytopenia due to Platelet Clumping: A Case Report and Brief Review of the Literature

Obtain a sample in ammonium oxalate, and count platelets utilizing a hemocytometer grid, if available, as per described methods [ 4 ]. Thank you for your question, and as always, I invite comments from our participants.

Pseudothrombocytopenia or spurious thrombocytopenia is an in-vitro sampling problem cpumped may mislead the diagnosis towards the more critical condition of thrombocytopenia. Physical examination was unremarkable. Platelet satellitism was first reported in the early ‘s.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any clumpd, provided the original work is properly cited. Repeat testing of the new sample presumed to be collected in heparin showed normal platelet count. Platelet clumping is a common laboratory phenomenon that complicates or precludes reporting of platelet count.

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The patient presented with extensive bruising.

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A pseudothrombocytopenia false-positive result may occur when automated platelet counting devices are used. Abstract Platelet clumping is a common laboratory phenomenon that complicates or precludes reporting of platelet count. The use plateletw an alternate anticoagulant, such as citrate or heparin, may be helpful. Hemoglobin Hgb and WBC were normal. Platelet satellitism and platelet clumping can cause pseudo-thrombocytopenia.

By Director Dennis Ernst. Online laboratory continuing education for clinical laboratories and med techs.

A photomicrograph of her stained PB smear is provided in Figure 1. The authors declare that there are no competing interests regarding the publication of this paper.

Please help to improve this article by introducing more precise citations. Aug 31, 1: Received Sep 16; Accepted Nov 8. Support Center Support Center. Upon examination of peripheral blood PB smear, clumping of platelets was observed. If the instruments’ platelet count of a sample is within or above normal range, a count may be given with an added comment noting the presence of platelet clumps and suggesting that the true count is likely higher than reported.

The image on the right illustrates platelet satellitism with platelets adhering to a neutrophil. Platelets can then be counted using the automated method.

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